Take this medicine only as directed by your doctor. Do not take more or less of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of unwanted effects.

Dosing

The dose of these medicines will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

For aminocaproic acid
• To prevent or treat serious bleeding:
  • For oral dosage forms (syrup or tablets):
    • Adults For the first hour, the dose is 5 grams. Then the dose is 1 or 1.25 grams per hour for eight hours.
    • Children Dose is based on body weight or size and must be determined by your doctor. For the first hour, the dose is usually 100 milligrams (mg) per kilogram (kg) (45.4 mg per pound) of body weight. Then the dose is 33.3 mg per kg (15.1 mg per pound) of body weight per hour.
  • For injection dosage form:
    • Adults At first, the dose is 4 to 5 grams injected into a vein, over a period of one hour. Then the dose is 1 gram per hour, injected into a vein over a period of eight hours.
    • Children Dose is based on body weight or size and must be determined by your doctor. At first, the dose is usually 100 mg per kg (45.4 mg per pound) of body weight, injected into a vein over a period of one hour. Then the dose is 33.3 mg per kg (15.1 mg per pound) of body weight per hour, injected into a vein.

For tranexamic acid
• To prevent or treat serious bleeding after dental surgery:
  • For oral dosage form (tablets):
    • Adults and children Dose is based on body weight and must be determined by your doctor. The dose is usually 25 milligrams (mg) per kilogram (kg) (11.4 mg per pound) of body weight every six to eight hours, beginning one day before surgery. After surgery, the dose is usually 25 mg per kg (11.4 mg per pound) of body weight every six to eight hours for two to eight days.
  • For injection dosage form:
    • Adults and children Dose is based on body weight and must be determined by your doctor. The dose is usually 10 mg per kg (4.5 mg per pound) of body weight, injected into a vein just before surgery. After surgery, the dose is usually 10 mg per kg (4.5 mg per pound) of body weight, injected into a vein every six to eight hours for seven to ten days.

Missed dose

• For aminocaproic acid (e.g., Amicar): If you miss a dose, take it as soon as possible. However, if you do not remember until it is almost time for your next dose, double the next dose. Then go back to your regular dosing schedule.
• For tranexamic acid (e.g., Cyklokapron): If you miss a dose, take it as soon as possible. Then take any remaining doses for the day at regularly spaced times. Do not double doses. If you have any questions about this, check with your doctor.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store the tablet form of this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For antifibrinolytic agents, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to aminocaproic acid or tranexamic acid. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy Studies on birth defects have not been done in humans. However, these medicines have been given to pregnant women without causing birth defects or other problems.

Studies on effects of aminocaproic acid in pregnancy have not been done in animals. Tranexamic acid has not been shown to cause birth defects or other problems in animal studies.

Breast-feeding These medicines have not been reported to cause problems in nursing babies. However, small amounts of tranexamic acid pass into the breast milk.

Children Although there is no specific information comparing use of aminocaproic acid or tranexamic acid in children with use in other age groups, these medicines are not expected to cause different side effects or problems in children than they do in adults.

Older adults

• For aminocaproic acid: Although there is no specific information comparing use of aminocaproic acid in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
• For tranexamic acid: Tranexamic acid has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

• Blood clots or a history of medical problems caused by blood clots or
• Blood in the urine or
• Color vision problems or
• Heart disease or
• Kidney disease or
• Liver disease The chance of side effects may be increased