Take mitotane only as directed by your doctor. Do not take more or less of it, and do not take it more often than your doctor ordered.

Do not stop taking this medicine without first checking with your doctor. To do so may increase the chance of unwanted effects.

Dosing

The dose of mitotane will be different for different patients. The dose that is used may depend on a number of things, including what the medicine is being used for and whether or not other medicines are also being taken. If you are taking mitotane at home, follow your doctor's orders or the directions on the label. If you have any questions about the proper dose of mitotane, ask your doctor.

Missed dose

If you miss a dose of this medicine, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and do not double the next one. Instead, go back to your regular dosing schedule and check with your doctor.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mitotane, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to mitotane. Also tell your health care professional if you are allergic to any other substance, such as foods, preservatives, or dyes.

Pregnancy Mitotane has not been shown to cause problems in humans.

Breast-feeding Although it is not known whether mitotane passes into the breast milk, it has not been reported to cause problems in nursing babies.

Children Although there is no specific information about the use of mitotane in children, it is not expected to cause different side effects or problems in children than it does in adults.

Older adults Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information about the use of mitotane in the elderly.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking mitotane, it is especially important that your health care professional know if you are taking any of the following:

• Central nervous system (CNS) depressants CNS depressant effects may be increased

• Infection

• Liver disease Effects may be increased because of slower removal of mitotane from the body